I take about 60 mg per day for arthritis and PPSD. Each person will have different dosing. It knocks the PPSD right out within minutes. Antidepressants are not like that and have crazy side effects and take pleasure away along with other feelings. It is very subtle and you may not notice it happening. But take it for a year and then go without it and you then can tell the difference. You cannot over dose. It works for me and if it is a placebo effect, I'll still take it. I find it is better to take it with other cannabis products with terpenes and THC. Not all cannabis is created equal and different strains work better than others for different ailments. Sativa seems to make me more anxious and don't like the feeling of the high much. The indica is more relaxing for me and helps with same of my issues. I can move my joints now without too much pain. It is not a cure all ,but my pain is 75% controlled. I don't take anymore pills for pain and my anxiety is almost gone completely. I'll take a placebo effect any day over dangerous medication, if it is a placebo effect.